Molecular Characterization of Probiotic Bacteria and Infectious Pathogens

Research into health-promoting probiotics and health-damaging bacterial pathogens of foodborne- and tickbrone-origin

Microbes are found in tremendous numbers everywhere in nature. Among these, there are microbes that are good for human health, and those that are bad for it. In our laboratory, we focus on lactic acid bacteria that are good for human health, and on bacterial pathogens of foodborne- and tickborne-origin causing emerging infectious diseases that are bad for human health.

1. Characterization of lactic acid bacteria isolated from plant-fermented foods, especially Japanese pickles, to develop new probiotic and functional foods
2. Molecular characterization of antibiotic-resistant bacteria isolated from food-producing animals, and molecular mechanisms of intracellular or intestinal infections of Listeria and E. coli (foodborne infection)
3. Molecular epidemiology of bacterial pathogens, especially obligatory intracellular parasites transmitted by ticks, and the analysis of the mechanisms of such bacteria by proteomics and cDNA microarray (tickborne infection)


Norio OhashiPhD


Yuko ShimamuraPhD

Details are here




Adhesion of a new probiotic bacterial candidate to the Caco-2 human colonic carcinoma cell line used as a model of epithelial cells on intestine


THP-1 human acute leukemia cell line infected with an obligatory intracellular parasite, Anaplasma phagocytophilum (3-D imaging) Red arrow: intracellular inclusion of live Anaplasma bacteria Yellow arrow: THP-1 host cell nucleus


  1. J. Vet. Med. Sci. in press.
  2. Jpn. J. Infect. Dis. 65, 79-83 (2012)
  3. J. Med. Microbiol. 60, 780-786 (2011).
  4. Jpn. J. Infect. Dis. 64, 153-155 (2011)
  5. J. Vet. Med. Sci. 73, 1485-1488 (2011)
  6. PLoS One 22, e11718 (2010)
  7. Biosci. Biotech. Biochem. 74, 812-818 (2010)
  8. Int. J. Cancer 127, 2685-2698 (2010)
  9. J. Med. Microbiol. 58, 1638-1644 (2009)
  10. Jpn. J. Infect. Dis. 62, 142-145 (2009)