Human Genetics

A new approach for establishing preventive methods for lifestyle-related disease

Using Drosophila genetics for understanding human metabolic diseases

The prevalence of lifestyle-related diseases such as diabetes, hypertension, and obesity are continuously increasing in many countries, including Japan. Although the precise mechanisms underlying the development and progression of such diseases have not been elucidated, a combination of multiple genetic and environmental factors is considered to contribute to the pathogenesis of such diseases. It will be crucial to gather scientific evidence of any interactions between genetic and environmental factors to establish preventive methods for lifestyle-related diseases.


1. Interaction of genetic and environmental factors related to the development of lifestyle-related diseases
With the recent progress of genome science, many susceptibility genes for lifestyle-related diseases have been identified. In our laboratory, we analyze a variety of interactions between such susceptibility genes and dietary nutrient intake to better understand how these interactions affect the development of lifestyle-related diseases.
2. Functional analysis of genes related to lifestyle-related diseases using fruit fly Drosophila melanogaster
Many of the genes implicated in human metabolic diseases also exist in Drosophila. Analysis of Drosophila genetics is a powerful tool to expand and deepen our understanding of the metabolic processes underlying lifestyle-related diseases.
3. Detection of bioactive food components by Drosophila genetics
We have developed a method for using Drosophila to screen bioactive food components. Drosophila genetics can provide new insight into the functional compounds of food components.

Professor

Kimiko KobayashiPhD
kobayasi@u-shizuoka-ken.ac.jp
TEL.+81-54-264-5220

Professor

Yuya OhharaPhD

Details are here

http://dfns.u-shizuoka-ken.ac.jp/labs/cellphys/index.html

 

Figure.1

Lifestyle-related diseases are complex multifunctional disorders.

Figure.2

Octβ1 knockdown flies are sensitive to starvation.

References

  1. BMC Medical Genetics [in press]
  2. Zoolog. Sci., 29, 83–89 (2012)
  3. Obesity 19, 882–877 (2011)
  4. J. Hum. Genet, 54, 474–478 (2009)