Environmental Bioengineering

Green-White Biotechnology

Applied microbiology for sustainable environment and food production.

Our aim of study is addition of value for food residues, such as residual non-food parts and byproducts from food production processes. Our approach is producing valuable products from food residues by microbial fermentation. Our main target product is fine chemical (e.g., supplement, functional food, food additives, feed supplement and functional fertilizers) that maintain and stimulate health of animal and crops (Figure 1). We are challenging to improve microbial cell factories to develop lower energy required, higher efficient and ecological friendly bioprocess converting ecologically negative resources to value-added fine chemicals.

1. Conversion of food residues to ingredients for microbial fermentation
In many cases, it is difficult to use food residues directly as ingredients for microbial fermentation. We are developing methods to treat these resources for easy utilization by microorganisms.
2. Assessment and improvement of microbial cell factories.
We study to measure fundamental metabolic parameters of microorganisms owing to fermentation performance, especially energy and redox metabolism. We are engineering these metabolisms to improve microorganisms to develop tough and efficient cell factories for production.
3.  Improvement of fine chemical fermentation.
We improve microbial fine chemical fermentation. To date, we improve yeast to enhance productivity of glutathione as a supplement and functional food for health of human, astaxanthin as feed supplement for health of fish, and 5’-amino levulinic acid as functional fertilizer for health of crops.


Kiyotaka HaraPhD


Takahiro SekikawaPhD


Details are here



Figure.1 Fine chemical production from food residues

Fine chemical production from food residues

Figure.2 An example of fermentation of food residues using engineered microorganisms

An example of fermentation of food residues using engineered microorganisms


  1. Science. 353, 6305 (2016)
  2. Appl Microbiol Biotechnol. 99, 9771-9778 (2015)
  3. Microb Cell Fact. 14, 56 (2015)
  4. Bioinformatics. 31, 905-911 (2015)
  5. Microb Cell Fact. 13, 175 (2014)
  6. Microb Cell Fact. 13, 175 (2014)
  7. Appl Microbiol Biotechnol. 98, 6787-6793 (2014)
  8. Sci Rep. 3, 1635 (2013)
  9. Bioresour Technol. 135, 513-522 (2013)
  10. Biotechnol J. 7, 686-689 (2012)